Abstract

Currently, osteoporosis is mainly diagnosedthrough dual-energy X-ray absorptiometry (DXA). However,DXA cannot be used for early diagnoses through populationmass screenings because of issues related to ionizingradiation employment. This paper describes the diagnosticaccuracy of a novel ultrasound (US)-based method toperform spinal densitometry without employing X-rays. Theproposed innovative methodology is based on a combinedanalysis of both echographic images and "raw"radiofrequency US signals. The diagnostic output isrepresented by the same parameters of DXA (bone mineraldensity (BMD), T-score, Z-score). The actual effectivenessof the proposed methodology was evaluated on a cohort of350 normal-weight or underweight (body mass index (BMI)< 25 kg/m2) female patients in the age range 45-65 years bya direct comparison with DXA assumed as gold standard.The accuracy of US-based diagnoses ranged from amaximum of 90.5% to a minimum of 74.1%, correspondingto the youngest and oldest patient age category, respectively,with an average of 84.9%. A good correlation was alsofound between US-estimated BMD and DXA related values(r=0.69, p<0.001). Obtained results demonstrated the highaccuracy of the proposed US approach to spinal bonedensitometry compared with DXA. This technique has thepotential to become a useful and effective tool in clinicalpractice improving the current approach to osteoporosisdiagnosis.

Autore Pugliese

• Casciaro Ernesto , Conversano Francesco , Casciaro Sergio

Tutti gli autori

• M. D. Renna; F. Conversano; P. Pisani; E. Casciaro; L. Quarta; D. Costanza; M. Muratore ; S. Casciaro

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2014

ISSN

Non Disponibile

ISBN

978-92-990073-5-8

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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