Development of a rapid and sensitive HPLC method for the identification and quantification of cavoxin and cavoxone in Phoma cava culture filtrates

Abstract

Cavoxin is a tetrasubstituted phytotoxic chalcone and cavoxone is the correponding chroman-4-one, bothproduced in vitro by Phoma cava, a fungus isolated from chestnut. Cavoxin showed biofungicidepotential against fungal species responsible of food molding. Therefore, cavoxin has potential to beincorporated into biopolymer to generate a so called "intelligent food packaging". To reach this objectivethe large scale production of cavoxin by P. cava fermentation need to be optimized. A rapid and efficientmethod for cavoxin analysis, as well as of cavoxone, in the fungal culture filtrates and thecorresponding organic extracts is the first experimental step. Thus, a HPLC method was developed andapplied to quantify cavoxin and cavoxone production in two different fungal culture conditions. Theanalysis proved that cavoxin production in stirred culture filtrates is significantly higher than in staticones.


Tutti gli autori

  • MASI M.; MOEINI S.A.; BOARI A.; CIMMINO A.; VURRO M.; EVIDENTE A.

Titolo volume/Rivista

Natural product research


Anno di pubblicazione

2018

ISSN

1478-6427

ISBN

Non Disponibile


Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile


Numero di citazioni Scopus

Non Disponibile

Ultimo Aggiornamento Citazioni

Non Disponibile


Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile