Development and validation of biomarkers to monitor human and animal exposure to the principal mycotoxins.

Abstract

This PhD thesis deals with the development/optimization and validation of a sensitive, accurate, precise and robust LC-MS/MS analytical method for the simultaneous determination of biomarkers of DON, AFB1, FB1, ZEA and OTA in human and animal urine. This method was in-house validated and revalidated in a mini-intercomparison study for human urine. The applicability of the new method to human urine samples was demonstrated in a human pilot study conducted in South Africa and South Italy. The results of this study showed an high percentage of positive samples for biomarkers of DON, FB1, ZEA and OTA in both countries.


Autore Pugliese

Tutti gli autori

  • Gambacorta L.

Titolo volume/Rivista

Non Disponibile


Anno di pubblicazione

2012

ISSN

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ISBN

978-88-6541-224-4


Numero di citazioni Wos

Nessuna citazione

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Numero di citazioni Scopus

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Settori ERC

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Codici ASJC

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