Abstract

Nanosized contrast agents for medical imaging arebeing increasingly studied because of their potential for directand selective targeting of diseased cells located in theextravascular compartment. Recently, our research group hasexperimentally investigated the echogenicity of silicananospheres (SiNSs), potentially useful for tumor targetingpurposes, demonstrating their contrast enhancement power onconventional ultrasound (US) images in a wide range of sizesand concentrations. In the present work, we evaluated the "invitro" cytotoxicity of SiNSs at variable concentration in humancervical cancer cell line (HeLa). Toxicity of SiNSs with diameterin our investigated range (160-330 nm) had never beenpreviously quantified, although this is the most promising sizeinterval for US targeted imaging. Our reported results indicateda SiNS concentration range which does not cause appreciabledecrements in cell survival, being therefore safely exploitable forcontrast-enhanced US imaging.

Autore Pugliese

• Conversano Francesco , Casciaro Sergio

Tutti gli autori

• Dipaola L.; Chiriacò F.; Sbenaglia E.A.; Conversano F.; Ragusa A.; Casciaro S.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2011

ISSN

Non Disponibile

ISBN

978-1-4244-9288-6

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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