Correlative Light and Scanning X-Ray Scattering Microscopy of Healthy and Pathologic Human Bone Sections
Abstract
Scanning small and wide angle X-ray scattering (scanning SWAXS) experiments were performed on healthy and pathologic human bone sections. Via crystallographic tools the data were transformed into quantitative images and as such compared with circularly polarized light (CPL) microscopy images. SWAXS and CPL images allowed extracting information of the mineral nanocrystalline phase embedded, with and without preferred orientation, in the collagen fibrils, mapping local changes at sub-osteon resolution. This favorable combination has been applied for the first time to biopsies of dwarfism syndrome and Paget's disease to shed light onto the cortical structure of natural bone in healthy and pathologic sections.
Autore Pugliese
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Giannini C.; Siliqi D.; Bunk O.; Beraudi A.; Ladisa M.; Altamura D.; Stea S.; Baruffaldi F.
Titolo volume/Rivista
Scientific reports
Anno di pubblicazione
2012
ISSN
2045-2322
ISBN
Non Disponibile
Numero di citazioni Wos
Nessuna citazione
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Numero di citazioni Scopus
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Settori ERC
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Codici ASJC
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