Congenital anomalies among live births in a polluted area. A ten-year retrospective study

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Abstract

Congenital anomalies and their primary prevention are a crucial public health issue. This work aimedto estimate the prevalence of congenital anomalies in Brindisi, a city in southeastern Italy at high risk ofenvironmental crisis.Methods: This research concerned newborns up to 28 days of age, born between 2001 and 2010 to mothersresident in Brindisi and discharged with a diagnosis of congenital anomaly. We classified cases according to thecoding system adopted by the European Network for the Surveillance of Congenital Anomalies (EUROCAT).Prevalence rates of congenital anomalies in Brindisi were compared with those reported by EUROCAT. Logisticregression models were adapted to evaluate the association between congenital anomalies and municipality ofresidence of the mother during pregnancy.Results: Out of 8,503 newborns we recorded 194 subjects with congenital anomalies (228.2/10,000 total births), 1.2times higher than the one reported by the EUROCAT pool of registries. We observed 83 subjects with congenitalheart diseases with an excess of 49.1%. Odds Ratios for congenital heart diseases significantly increased fornewborns to mothers resident in Brindisi (OR 1.75 CI 95% 1.30-2.35).Conclusions: Our findings indicated an increased prevalence of Congenital Anomalies (especially congenital heartdiseases) in the city of Brindisi. More research is needed in order to analyze the role of factors potentially involvedin the causation of congenital anomalies.

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  • Gianicolo E.A.L.; Bruni A.; Rosati E.; Sabina S.; Guarino R.; Padolecchia G.; Leo C.; Vigotti M.A.; Andreassi M.G.; Latini G.

Titolo volume/Rivista

BMC pregnancy and childbirth

Anno di pubblicazione

2012

ISSN

1471-2393

ISBN

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