Abstract

The assessment of osteoporotic fracture riskrequires the measurement of bone mineral density (BMD)on reference sites (hip and spine) and the evaluation ofclinical risk factors (CRFs) for fracture. The Fracture RiskAssessment algorithm (FRAX®), internationally recognizedby official guidelines for osteoporotic patient management,represents a tool for estimating 10-year probability of hipand major fragility fractures by integrating CRFs andfemoral neck BMD or T-score, when available. In this workwe presented an innovative ultrasound (US)-based methodfor estimating fracture risk by means of a safe and radiationfreeapproach. From abdominal ultrasound scans performedon 64 female patients, we defined and quantified a new USdiagnostic parameter named Fragility Score (F.S.), whichestimates bone fragility. Obtained results showed an highPearson correlation coefficient between fractureprobabilities calculated by FRAX® and F.S. (r up to 0.75 inthe case of FRAX® estimates including femoral neck BMDand r=0.71 in the case of FRAX® estimates based onfemoral neck T-score). The present study demonstrated thefeasibility of a novel US approach for fracture riskprediction and prevention, directly applicable on spine andindependent from BMD measurements and CRFassessments. The proposed methodology could represent avalid alternative to both FRAX® and BMD for earlyassessment of fracture risk.

Autore Pugliese

• Conversano Francesco , Casciaro Sergio

Tutti gli autori

• A. Greco; P. Pisani; G. Soloperto; M.D. Renna; F. Conversano; M. Muratore; S. Casciaro

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2014

ISSN

Non Disponibile

ISBN

978-92-990073-5-8

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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