Abstract

Multimodal contrast agents (CAs) allow theenhancement of medical images acquired through differenttechniques by employing a single contrast injection, withsignificant benefits for diagnostic outcome. The present study isfocused on the characterization of the magnetic behavior of anovel CA class, consisting of silica (Si) nanoparticles (NPs)covered by either superparamagnetic iron oxide (SPIO) NPs orFePt-IO nanocrystals and designed to be detected through bothultrasound and magnetic resonance imaging (MRI). The usemultimodal nanoparticles as negative MRI contrast agents couldopen up new perspectives for the development of novel tools fornanomedicine, combining different non-ionizing techniques fortargeted imaging of specific diseased cells. In this work, wesimulated the MRI signal of a blood vessel in presence of the newbimodal CAs and compared it with the response of thesuperparamagnetic NPs alone. The performed numericalsimulations showed that the magnetic response of the novel nanocomposites,in terms of signal magnitude, was similar to that ofthe conventional superparamagnetic NPs for values of echo time(TE) shorter than 0.4 ms, while for longer TE values it was evenbetter, showing a stronger vessel enhancement leading to aneasier detection of the smaller vessels. Therefore, the testedbimodal NPs have the potential for an effective employment asMRI CAs.

Autore Pugliese

• Casciaro Ernesto , Conversano Francesco , Franchini Roberto , Casciaro Sergio

Tutti gli autori

• R. Franchini; E. Casciaro; F. Conversano; A. Lay-Ekuakille; S. Casciaro

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2015

ISSN

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ISBN

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Numero di citazioni Wos

Nessuna citazione

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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