Abstract

Core-shell iron oxide-gold nanoparticles (Fe3O4@Au) can be considered a smart platform for polyvalent presentation on account of their globular shape, tunable size, facile surface chemistry, and biocompatibility. We reported the synthesis and the characterization of Fe3O4@Au nanoparticles with transmission electron microscopy (TEM), dynamic light scattering (DLS), ultraviolet visible spectroscopy (UV-Vis), and we investigated their applicability as contrast agents for Magnetic Resonance Imaging (MRI). The measurement of longitudinal and transverse relaxation times of water protons in homogeneous aqueous dispersions of Fe3O4@Au nanoparticles with biocompatible coating at different concentrations allowed the assessment of longitudinal (r1) and transverse (r2) relaxivities at 1.5 and 3 T. The use of conjugated Fe3O4@Au nanoparticles as negative contrast agents could open up new perspectives for the development of novel tools for nanomedicine and for targeted delivery-MRI contrast enhancement systems and photo-optical applications in biomedicine.

Autore Pugliese

• Conversano Francesco , Casciaro Sergio

Tutti gli autori

• L. Menichetti; D. Arosio; D. De Marchi; L. Paduano; A. Flori; F. Conversano; S. Casciaro; V. Positano; L. Manzoni

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2011

ISSN

Non Disponibile

ISBN

9781424492893

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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