Abstract

Fumonisins are a family of carcinogenic secondarymetabolites produced by members of the Fusariumfujikuroi species complex (FFSC) and rare strains ofFusarium oxysporum. In Fusarium, fumonisin biosyntheticgenes (FUM) are clustered, and the cluster isuniform in gene organization. Here, sequence analysesindicated that the cluster exists in five differentgenomic contexts, defining five cluster types. In FUMgene genealogies, evolutionary relationships betweenfusaria with different cluster types were largely incongruentwith species relationships inferred fromprimary-metabolism (PM) gene genealogies, and FUMcluster types are not trans-specific. In addition, synonymoussite divergence analyses indicated that threeFUM cluster types predate diversification of FFSC. Thedata are not consistent with balancing selection orinterspecific hybridization, but they are consistentwith two competing hypotheses: (i) multiple horizontaltransfers of the cluster from unknown donors to FFSCrecipients and (ii) cluster duplication and loss (birthand death). Furthermore, low levels of FUM gene divergencein F. bulbicola, an FFSC species, and F. oxysporumprovide evidence for horizontal transfer of thecluster from the former, or a closely related species, tothe latter. Thus, uniform gene organization within theFUM cluster belies a complex evolutionary history thathas not always paralleled the evolution of Fusarium.

Autore Pugliese

• Susca Antonia , Moretti Antonio , Stea Gaetano

Tutti gli autori

• R.H. Proctor ; F. Van Hove; A. Susca; G. Stea; M. Busman; T. van der Lee; C. Waalwijk; A. Moretti; T.J. Ward

Titolo volume/Rivista

Molecular microbiology

Anno di pubblicazione

2013

ISSN

0950-382X

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

Non Disponibile