Abstract

Artemisinin is a sesquiterpene antimalarialcompound produced, though at low levels (0.1-1% dryweight), in Artemisia annua in which it accumulates in theglandular trichomes of the plant. Due to its antimalarialproperties and short supply, efforts are being made toimprove our understanding of artemisinin biosynthesis andits production. Native ?-cyclodextrins, as well as thechemically modified heptakis(2,6-di-O-methyl)-?-cyclodextrin(DIMEB) and 2-hydroxypropyl-?-cyclodextrins,were added to the culture medium of A. annua suspensioncultures, and their effects on artemisinin production wereanalysed. The effects of a joint cyclodextrin and methyljasmonate treatment were also investigated. Fifty millimolarDIMEB, as well as a combination of 50 mMDIMEB and 100 ?M methyl jasmonate, was highlyeffective in increasing the artemisinin levels in the culturemedium. The observed artemisinin level (27 ?mol g-1 dryweight) was about 300-fold higher than that observed inuntreated suspensions. The influence of ?-cyclodextrinsand methyl jasmonate on the expression

Autore Pugliese

• De Paolis Angelo , Mita Giovanni , Durante Miriana , Caretto Sofia Pia Anna

Tutti gli autori

• Durante M.; Caretto S.; Quarta A.; De Paolis A.; Nisi R.; Mita G.

Titolo volume/Rivista

Applied microbiology and biotechnology

Anno di pubblicazione

2011

ISSN

0175-7598

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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