Abstract

Hydroxytyrosol (2-(3,4dihydroxyphenyl)ethanol, (DPE), a phenolic compound present in oliveoil, is known to have antioxidant properties. The aim of this study was to investigate the effectof DPE on oxidative stress induced by cadmium injections (CdCl2 2.5 mg/kg body weight)in spleen and testes of adult male rats. Oxidative stress was evaluated by measuring lipidperoxidation by thiobarbituric acid reactive substances (TBARS) as well as superoxide dismutase(SOD) and catalase (CAT) activities in cytosol and mitochondria.We found that in spleen no TBARS formation was detected following CdCl2 injections; however,DPE induces decrease in TBARS level in treated and untreated rats. On the contrary, weobserved that DPE showed no effect on cadmium-induced lipid peroxidation in testes.Cytosolic activities of SOD and CAT decreased significantly only in spleen, where DPE restoresthe values to the control levels. Noteworthy, mitochondrial activities of SOD and CAT werestrongly reduced by cadmium treatment both in spleen and testes, and DPE was not be able torestore their activity. Overall, the results from this study indicated that the DPE has differentantioxidant efficiency in spleen and testis of cadmium intoxicated rats.

Autore Pugliese

• Bobba Antonella

Tutti gli autori

• Merra E.; Calzaretti G.; Bobba A.; Storelli M.M.; Casalino E.

Titolo volume/Rivista

Drug and chemical toxicology

Anno di pubblicazione

2014

ISSN

0148-0545

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

Non Disponibile