Abstract

Bergamot, the common name of the fruit Citrus bergamia Risso, is cultivated in a verythin strip Ionian coastline in Southern Italy, near Reggio Calabria. Several health effects ofbergamot fruits are mainly related to their polyphenol content (Gabriele, M. et al., 2017).Bergamot fruits are commonly exploited for the outer peel mostly used for the essence productionwhilst recently the juice has gained considerable attention as potential agents forprevention and treatment of oxidative stress-related diseases. Nevertheless, the most partof fruits is disposed as waste product. In this work, a patented lyophilized Citrus bergamiadietary supplement (BergaLioTM, Patent N°102018000003303, Longo G.M.M.), marketed forits proved antioxidant and anti-inflammatory properties, was extracted in water at 50 °C for24 hours (Caputo et al., 2018). The extract was assayed for the antimicrobial activity againstseveral Staphyloccoccus spp. strains, generally associated with atopic dermatitis and urinarytract infections (Flores-Mireles et al., 2015; Musthaq et al., 2018). The results showed highinhibitory activities mostly against, S. epidermidis UR63 and S. saprophyticus UR18. Also 4Pseudomonas fluorescens and 1 P. putida strains, recently found to trigger pathogenesis indebilitated and immune-compromised patients (Nishimura et al., 2017; Fernández et al.,2015), were strongly inhibited. RP-HPLC profile of BergaLioTM showed the abundance ofhesperedin, quercetin and apigenin derivates, that, could be putatively involved in the antimicrobialactivity, as demonstrated for other Citrus extracts.Although further studies are needed, this work adds new knowledge to the health benefitsof BergaLioTM suggesting its exploitation, in combination with the conventional therapiesagainst several human skin commensal bacteria and opportunistic pathogens correlatedwith nosocomial infections.

Autore Pugliese

• D'antuono Isabella

Tutti gli autori

• L. Caputo; G.M.M. Longo; I. D'Antuono; V. Linsalata; A. Cardinali; V. Calabrò; G. Lentini; M.M. Cavalluzzi; L. Quintieri

Titolo volume/Rivista

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Anno di pubblicazione

2019

ISSN

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ISBN

9788880803362

Numero di citazioni Wos

Nessuna citazione

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