An innovative ultrasound-based method for the identification of patients at high fracture risk

Torna indietro

Abstract

The clinical significance of osteoporosis liesin the relevant occurrence of fractures. Osteoporosis affectsabout 200 million people in the world and is responsible for8.9 million fractures each year worldwide. Hip fractures area major public health burden, from both social andeconomic point of view, since they represent one of the mostimportant causes of morbidity, disability, decreased qualityof life and mortality for the elderly population. It has beendemonstrated that bone mineral density (BMD)measurements on lumbar spine or proximal femur,standardly evaluated by dual-energy X-ray absorptiometry(DXA) examinations, are the most reliable available tool topredict the general risk of osteoporotic fractures. However,DXA, bearing X-ray related issues, is inadequate forpopulation screening purposes and early diagnosis. In thepresent work, we present a new ultrasound (US)-basedmethod and evaluate its performance for the prediction ofosteoporotic fractures. We enrolled 40 women with recentnon-vertebral osteoporotic fractures (frail subjects) and 44controls without fracture history (non-frail subjects): thissample was used to compare the discriminatory power of thenovel US methodology applied on spine with lumbar DXAby building the corresponding Receiver OperatingCharacteristic (ROC) curves. Obtained results showed thatthe new proposed US parameter (named Fragility Score,F.S.) is suitable for population screening purposes, since itsArea Under the Curve (AUC) was the same of DXAmeasuredBMD (0.77) but it was coupled with a bettersensitivity (83% vs 68%) in identifying patients at high riskof osteoporotic fracture.

Autore Pugliese

Tutti gli autori

  • P. Pisani; A. Greco; M. D. Renna; F. Conversano; E. Casciaro; L. Quarta; D. Costanza; M. Muratore; S. Casciaro

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2014

ISSN

Non Disponibile

ISBN

978-92-990073-5-8

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

Non Disponibile

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile