Abstract

Every biomedical imaging technique exploitsdifferent physical principles and can provide peculiarinformation, which is often unachievable with differenttechniques and can be further enhanced by the employment ofsuitable contrast agents (CAs). However, each imaging techniquetypically requires its own specific CAs, with correspondingincrements of procedure duration, costs and invasiveness for thepatients, who should undergo two injections. In the last years,great effort has been addressed toward the development ofmultimodal CAs that can be real-time detected by differenttechniques. In this context, we developed a new type of bimodalnanoparticles (NPs), consisting of silica nanospheres (NSs)covered by an outer shell of smaller superparamagnetic NPs, tobe used as dual-mode imaging CAs for ultrasound and magneticresonance imaging techniques. Aim of the present study was toevaluate the echographic detectability of these bimodal NPsthrough a recently developed algorithm that was originallyimplemented to detect pure silica NSs. In particular, weperformed a series of "in vitro" experiments on custom-designedtissue-mimicking phantoms, focused on a specific objective ofdirect clinical interest: the detection of multimodal NPs with adiameter of about 330 nm at a low and biocompatible volumeconcentration (0.2%). The obtained results demonstrated thepossibility of deleting the US echoes coming from structuresother than NPs with high effectiveness, therefore enhancing thebrightness of nanosized contrast agents in the final diagnosticimages. The effectiveness of the proposed method shows verypromising perspectives for future clinical applications.

Autore Pugliese

• Conversano Francesco , Di Paola Marco , Franchini Roberto , Casciaro Sergio

Tutti gli autori

• F. Conversano; R. Franchini; P. Pisani; A. Greco;M. Di Paola; S. Casciaro.

Titolo volume/Rivista

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Anno di pubblicazione

2015

ISSN

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ISBN

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Numero di citazioni Wos

Nessuna citazione

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Numero di citazioni Scopus

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Settori ERC

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Codici ASJC

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