Abstract

Inflammatory bowel diseases (IBD) are debilitating chronic inflammatory disordersthat develop as a result of a defective immune response toward intestinal bacteria. Intestinaldysbiosis is associated with the onset of IBD and has been reported to persist even in patientsin deep remission. We investigated the possibility of a dietary-induced switch to the gut microbiotacomposition using Winnie mice as a model of spontaneous ulcerative colitis and chow enriched with1% Bronze tomato. We used the near isogenic tomato line strategy to investigate the effects of adiet enriched in polyphenols administered to mild but established chronic intestinal inflammation.The Bronze-enriched chow administered for two weeks was not able to produce any macroscopiceffect on the IBD symptoms, although, at molecular level there was a significant induction ofanti-inflammatory genes and intracellular staining of T cells revealed a mild decrease in IL17A andIFN production. Analysis of the microbial composition revealed that two weeks of Bronze enricheddiet was sufficient to perturb the microbial composition of Winnie and control mice, suggestingthat polyphenol-enriched diets may create unfavorable conditions for distinct bacterial species.In conclusion, dietary regimes enriched in polyphenols may efficiently support IBD remissionaffecting the intestinal dysbiosis.

Autore Pugliese

• Santino Angelo

Tutti gli autori

• M. Liso; S. De Santis; A. Scarano; G. Verna M. Dicarlo;V. Galleggiante; P. Campiglia; M. Mastronardi; A. Lippolis;M. Vacca; A. Sobolewski; G. Serino; E. Butelli;M. De Angelis; C. Martin; A. Santino; M. Chieppa

Titolo volume/Rivista

Nutrients

Anno di pubblicazione

2018

ISSN

2072-6643

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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