Abstract

The detailed action mechanism of volatile general anesthetics is still unknown despite their effect has been clinically exploited for more than a century. Long ago it was also assessed that the potency of an anesthetic molecule well correlates with its lipophilicity and phospholipids were eventually identified as mediators. As yet,the direct effect of volatile anesthetics at physiological relevant concentrations on membranes is still under scrutiny. Organic field-effect transistors(OFETs)integrating a phospholipid (PL) functional biointer-layer(FBI)are here proposed for the electronic detection of archetypal volatile anesthetic molecules such as diethylether and halothane. This technology allows to directly interface a PL layer to an electronic transistor channel,and directly probe subtle changes occurring in the bio-layer. Repeatable responses of PLFBI-OFET to anesthetics are produced in a concentration range that reaches few percent,namely the clinically relevant regime. The PLFBI-OFET is also shown to deliver a comparably weaker response to a non-anesthetic volatile molecule such as acetone

Autore Pugliese

• Scamarcio Gaetano , Palazzo Gerardo , Sabbatini Luigia , Torsi Luisa , Cioffi Nicola

Tutti gli autori

• SCAMARCIO G.;PALAZZO G.;SABBATINI L.;TORSI L.;MAGLIULO M.;CIOFFI N.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2013

ISSN

0956-5663

ISBN

Non Disponibile

Numero di citazioni Wos

10

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

Non Disponibile

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile