Therapeutic potential of the endocrine fibroblast growth factors FGF19, FGF21 and FGF23

Abstract

The endocrine fibroblast growth factors (FGFs), FGF19, FGF21 and FGF23, are critical for maintaining whole-body homeostasis, with roles in bile acid, glucose and lipid metabolism, modulation of vitamin D and phosphate homeostasis and metabolic adaptation during fasting. Given these functions, the endocrine FGFs have therapeutic potential in a wide array of chronic human diseases, including obesity, type 2 diabetes, cancer, and kidney and cardiovascular disease. However, the safety and feasibility of chronic endocrine FGF administration has been challenged, and FGF analogues and mimetics are now being investigated. Here, we discuss current knowledge of the complex biology of the endocrine FGFs and assess how this may be harnessed therapeutically.


Tutti gli autori

  • MOSCHETTA A.;SABBA' C.

Titolo volume/Rivista

Non Disponibile


Anno di pubblicazione

2016

ISSN

1474-1776

ISBN

Non Disponibile


Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile


Numero di citazioni Scopus

87

Ultimo Aggiornamento Citazioni

Non Disponibile


Settori ERC

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Codici ASJC

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