The therapeutic potential of 5-HT1A receptors: a patent review.

Torna indietro

Abstract

Introduction: The 5-HT1A receptors are implicated in mood disorders (anxiety, depression), in cognition, and in modulation of pain. Nearly 30 years of research in this field, there is still interest in developing new chemical entities capable of 5-HT1A receptor activation or blockade. 10 Areas covered: This review article will highlight and review the research advances published in the patent literature between January 2007 and December 2011, giving emphasis to the medicinal chemist’s standpoint. Literature search methodology included search in Scifinder and PubMed Databases and browsing clinicaltrials.gov website. 15 Expert opinion: Almost no new therapeutic applications have been proposed for molecules targeting the 5-HT1A receptor, during the years covered by the present review. The discovery that stimulation of 5-HT1A receptor can promote neurogenesis will likely renew the interest for selective 5-HT1A receptor agonists as therapeutics to replace neural populations damaged by disease 20 or injury.

Autore Pugliese

Tutti gli autori

  • LACIVITA E.;BERARDI F.;LEOPOLDO M.;COLABUFO N.A.;PERRONE R.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2012

ISSN

1354-3776

ISBN

Non Disponibile

Numero di citazioni Wos

19

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

23

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile