The beta-adrenoceptor agonist isoproterenol promotes the activity of respiratory chain complex I and lowers cellular reactive oxygen species in fibroblasts and heart myoblasts

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Abstract

A study is presented on the effect of the beta-adrenoceptor agonist isoproterenol on mitochondrial oxygen metabolism in fibroblast and heart myoblast cultures. Isoproterenol treatment of serum-limited fibroblasts and proliferating myoblasts results in the promotion of mitochondrial complex I activity and decrease of the cellular level of reactive oxygen species. These effects of isoproterenol are associated with cAMP-dependent phosphorylation of complex I subunit(s). Addition of okadaic acid, inhibitor of protein phosphatase(s), reverses the decline of complex I activity in serum-limited fibroblast cultures and activates the complex in proliferating myoblast cultures. The effects of isoproterenol on complex I activity and reactive oxygen species balance can contribute to the therapeutic effect of the drug. (C) 2010 Elsevier B.V. All rights reserved.

Autore Pugliese

Tutti gli autori

  • SIGNORILE A.;PAPA F.;COCCO T.M.

Titolo volume/Rivista

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Anno di pubblicazione

2011

ISSN

0014-2999

ISBN

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Numero di citazioni Wos

Nessuna citazione

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Numero di citazioni Scopus

22

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Settori ERC

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Codici ASJC

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