Abstract

It is well known that resveratrol (RSV) displayed cancer-preventing and anticancer properties but its clinical application is limited because of a low bioavailability and a rapid clearance from the circulation. Aim of this work was to synthesize pharmacologically active resveratrol analogs with an enhanced structural rigidity and bioavailability. In particular, we have synthesized a library of 2,3-thiazolidin-4-one derivatives in which a thiazolidinone nucleus connects two aromatic rings. Some of these compounds showed strong inhibitory effects on breast cancer cell growth. Our results indicate that some of thiazolidin-based resveratrol derivatives may become a new potent alternative tool for the treatment of human breast cancer.

Autore Pugliese

• Tortorella Paolo

Tutti gli autori

• TORTORELLA P.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2013

ISSN

0960-894X

ISBN

Non Disponibile

Numero di citazioni Wos

31

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

33

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile