SETBP1 and miR_4319 dysregulation in primary myelofibrosis progression to acute myeloid leukemia.

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Abstract

The molecular pathogenesis underlying the primary myelofibrosis (PMF) progression to acute myeloid leukemia (AML) is still not well defined. The involvement of microRNA (miRNA) is actually helping to shed light on an important issue in the occurrence of myeloproliferative neoplasms (MPNs). However, the role of intronic miRNA, derived from the intron regions of gene transcripts, has never been reported in MPNs. In this study, we describe a PMF case evolved to AML with a t(12;18)(p13;q12) rearrangement showing the downregulation of the intronic miR_4319 and the overexpression of its host gene, SET binding protein (SETBP1). A possible molecular mechanism regulating the PMF progression to AML is discussed.

Autore Pugliese

Tutti gli autori

  • MINERVINI A.;ZAGARIA A.;ALBANO F.;SPECCHIA G.;ANELLI L.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2012

ISSN

1756-8722

ISBN

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Numero di citazioni Wos

12

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

14

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

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Codici ASJC

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