Abstract

Monocyte chemoattractant protein 1 (MCP-1) has been implicated in the recruitment of monocytes to atheroma and of monocytes and macrophages to adipose tissue. The aim of the study was to examine whether MCP-1 levels are associated independently with the main thermo-genetic hormones (serum TSH and thyroid hormones and 24-h urinary catecholamines) and insulin resistance in a population mainly represented by overweight and obese women. A cohort of 100 consecutive euthyroid women, aged 18–65 years, and with a wide range of BMI, was examined. Central fat accumulation (indirectly measured by waist circumference), fasting MCP-1 plasma levels, and TSH,FT3, FT4, insulin, glucose, and lipid(cholesterol, HDL- cholesterol and triglyceride) serum concentrations, and 24-h urinary catecholamines were measured. Insulin resistance was estimated by homeostasis model assessment forinsulin resistance (HOMAIR). MCP-1 levels were directly associated with BMI (<0.001), waist circumference (p<0.001), insulin (p< 0.001), HOMAIR (p< 0.001), diastolic blood pressure (DBP) (p< 0.001), systolic blood pressure (SBP) (p< 0.001), triglycerides (TG) (p<0.05), and 24-h urinary noradrenaline (p<0.05), and negatively correlated with HDL-cholesterol (p<0.01). When a multiple regression analysis was performed with MCP-1 as the dependent variable, and only parameters showing a significant univariate association with MCP-1 were considered as the independent variables, MCP-1 maintained an independent positive association with insulin (p<0.01), and DBP (p<0.05). When insulin was replaced by HOMAIR in the regression analysis, MCP-1 maintained an independent positive association with HOMAIR (p<0.05), DBP (p<0.05), and BMI (p<0.05). In conclusion, this study suggests that insulin, BMI, and diastolic blood pressure cooperate independently in increasing MCP-1 levels, whereas thyroid hormones and catecholamines have no apparent influence on this chemokine.

Autore Pugliese

• De Pergola Giovanni

Tutti gli autori

• DE PERGOLA G.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2010

ISSN

1973-798X

ISBN

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Numero di citazioni Wos

Nessuna citazione

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Settori ERC

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