Abstract

Raynaud's phenomenon (RP) is a well defined clinical syndrome characterized by recurrent episodes of digital vasospasm triggered by exposure to physical/chemical or emotional stress. RP has been classified as primary or secondary, depending on whether it occurs as an isolated condition (pRP) or is associated to an underlying disease, mainly a connective tissue disease (CTD-RP). In both cases, it manifests with unique “triple” (pallor, cyanosis and erythema), or “double” color changes. pRP is usually a benign condition, while sRP can evolve and be complicated by acral digital ulcers and gangrene, which may require surgical treatment. The pathogenesis of RP has not yet been entirely clarified, nor is it known whether autoantibodies have a role in RP. Even so, recent advances in our understanding of the pathophysiology have highlighted novel potential therapeutic targets. The aim of this review is to discuss the etiology, epidemiology, risk factors, clinical manifestations, recently disclosed pathogenic mechanisms underlying RP and their correlation with the available therapeutic options, focusing primarily on pRP and CTD-RP.

Autore Pugliese

• Favoino Elvira , Perosa Federico , Prete Marcella

Tutti gli autori

• FAVOINO E.;PEROSA F.;PRETE M.;FATONE M.C.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2014

ISSN

1568-9972

ISBN

Non Disponibile

Numero di citazioni Wos

39

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

46

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile