Abstract

Background: Adenosine intravenous infusion is used to evaluate Coronary Flow Reserve (CFR) in patients with coronary artery disease. However, the proposed duration of adenosine infusion ranges from 90 seconds to 5 minutes. Therefore the optimal duration of Adenosine infusion to obtain maximal vasodilator effect still remains uncertain. Aim: Purpose of this study was to define the optimal duration of adenosine intravenous (iv) infusion to elicit maximal coronary hyperemic effect. Materials and Methods: We consecutively enrolled 101 patients between June 2009 and May 2011. The mean age was 53±11 years (64% male, 36% female), and ejection fraction (EF) was 59±13%. All patients underwent blood flow velocity Doppler recording in the distal left anterior descending coronary artery (LAD) at baseline and during adenosine iv infusion via a pump at the dosage of 0.14 mg/Kg/min over 5 minutes. Coronary blood flow velocity in LAD was continuously recorded by a well-validated non invasive approach: enhanced transthoracic Color-guided Pulsed-Wave Doppler recording. The time to maximal hyperaemic effect was obtained by activating a built-in chronometer at the starting of adenosine infusion. Results: We found that the peak effect occurred at 72 ± 32 seconds (see histogram). The peak effect occurred within 90 sec in 80 pts (66%) and after 90 sec in 46 pts (34%). In no pt, peak hyperaemic effect took place beyond 3 minutes. In addition in the vast majority of cases (90%) the maximal vasodilatatory effect was reached before the tachycardic phase of adenosine effect. Conclusions: The results of this study seem to indicate that the optimal duration of adenosine infusion to evaluate CFR should be at least 3 minutes.

Autore Pugliese

• Caiati Carlo , Lepera Mario Erminio , Favale Stefano

Tutti gli autori

• CAIATI C.;LEPERA M.E.;FAVALE S.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2011

ISSN

1827-8981

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

Non Disponibile

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile