New isoforms of human mitochondrial transcription factor A detected in normal and tumoral cells

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Abstract

Novel alternatively spliced variants of the human mitochondrial transcription factor A predicted by the computational tool ASPic were experimentally validated in different normal and tumoral human tissues by RT-PCR and DNA sequencing. The comparison between the 5′UTR length and the distribution of the different transcripts showed that the transcripts with the shortest 5′UTR are present in all the investigated tissues, while the longest 5′UTR seems to be related to tissue-specificity. Studies about the localization and function of the most widely diffuse alternative isoform Tr6 were carried out.

Autore Pugliese

Tutti gli autori

  • DE VIRGILIO C.;GADALETA G.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2011

ISSN

1567-7249

ISBN

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Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

3

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

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Codici ASJC

Non Disponibile