Abstract

Recently a series of chiral N-(phenoxyalkyl)amides have been reported as potent MT1 and MT2 melatonergic ligands. Some of these compounds were selected and tested for their antioxidant properties by measuring their reducing effect against oxidation of 20,70-dichlorodihydrofluorescein (DCFH) in the DCFHdiacetate (DCFH-DA) assay. Among the tested compounds, N-[2-(3-methoxyphenoxy)propyl]butanamide displayed potent antioxidant activity that was stereoselective, the (R)-enantiomer performing as the eutomer. This compound displayed strong cytoprotective activity against H2O2-induced cytotoxicity resulting slightly more active than melatonin, and performed as Ca2+/calmodulin-dependent kinase II (CaMKII) inhibitor, too.

Autore Pugliese

• Carocci Alessia , Catalano Alessia , De Palma Annalisa , Franchini Carlo , Lentini Giovanni , Cavalluzzi Maria Maddalena

Tutti gli autori

• CAROCCI A.;CATALANO A.;DE PALMA A.;FRANCHINI C.;LENTINI G.;CAVALLUZZI M.M.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2013

ISSN

0968-0896

ISBN

Non Disponibile

Numero di citazioni Wos

24

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

23

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile