Abstract

Resveratrol is a natural phytoalexin present in a variety of plant species, such as grapes and red wine, that is well known for its anti-inflammatory effects. In addition, a cancer chemotherapeutic activity of resveratrol has been described. Here we evaluated the effect of resveratrol on COX-2 and prostaglandin E 2 production in human intestinal cells Caco-2 cells treated with lipopolysaccharide (LPS). Resveratrol concentration-dependently inhibited the expression of COX-2 mRNA in the LPS-treated cells, as well as protein expression, resulting in a decreased production of PGE 2. In order to investigate the mechanisms through which resveratrol exhibited these anti-inflammatory effects, we examined the activation of IκB in LPS-stimulated intestinal cells. Results demonstrated that resveratrol inhibited the translocation of NF-κB p65 subunits from the cytosol to the nucleus, which correlated with its inhibitory effects on IκBα phosphorylation and degradation. These results suggest that the down-regulation of COX-2 and PGE 2 by resveratrol may be related to NF-κB inhibition through the negative regulation of IKK phosphorylation in intestinal cells.

Autore Pugliese

• Panaro Maria Antonietta , Calvello Rosa

Tutti gli autori

• CIANCIULLI A.;PANARO M.A.;CALVELLO R.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2012

ISSN

0887-2333

ISBN

Non Disponibile

Numero di citazioni Wos

25

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

29

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile