Abstract

An efficient microwave-assisted synthesis of(±)-mandelic acid-5 was developed. e racemic mixture was resolved by diastereomeric salt formation using 1-phenylethylamine enantiomers as resolving agents. At each step, the resolution process was checked by determining mandelic acid-5 enantiomer ee values directly on fractional crystallized diastereomeric salts by chiral capillary electrophoresis analysis. Highly enriched (−)- and (+)-mandelic acid-5 (95% and 90% ee, resp.) were obtained and their absolute congurations— and , respectively—were determined by correlation of the (−)-mandelic acid-5 circular dichroism spectrum to the (R)-mande

Autore Pugliese

• Carocci Alessia , Catalano Alessia , Franchini Carlo , Lentini Giovanni , Cavalluzzi Maria Maddalena

Tutti gli autori

• CAROCCI A.;CATALANO A.;FRANCHINI C.;LENTINI G.;CAVALLUZZI M.M.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2013

ISSN

2090-9063

ISBN

Non Disponibile

Numero di citazioni Wos

2

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

2

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile