Immunopathogenesis of neurodegenerative diseases: current therapeutic models of neuroprotection with special reference to natural products

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Abstract

Parkinson disease (PD) and Alzheimer disease (AD) are neurodegenerative processes whose frequency is dramatically increasing in the western world. Both diseases share a common pathogenic denominator characterized by an exaggerated activation of the systemic and cerebral immune system, respectively. For instance, lipopolysaccharides in PD and amyloid beta in AD trigger microglia and astrocytes to release reactive oxygen species (ROS) and proinflammatory cytokines. Infiltrating peripheral T cells once activated in the central nervous system also contribute to the neurodegenerative process. Besides innovative biotherapy, nutraceuticals or functional foods are currently investigated for their neuroprotective activities. Especially, vitamin D and polyphenols, seem to be promising therapeutic tools for inhibiting ROS formation and arresting cytokine-mediated neuroinflammation in PD and AD.

Autore Pugliese

Tutti gli autori

  • JIRILLO E.;MAGRONE T.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2012

ISSN

1381-6128

ISBN

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Numero di citazioni Wos

33

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

35

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

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Codici ASJC

Non Disponibile