Frontal lobe metabolic alterations in autism spectrum disorder: a 1H-magnetic resonance spectroscopy study

Abstract

Recently, neuroimaging studies were performed using 1H-magnetic resonance spectroscopy (1H-MRS), revealing a quantitative alteration of neurochemicals (such as neurotransmitters and metabolites) in several brain regions of patients with autism spectrum disorder (ASD). The involvement of the frontal lobe in the neurobiology of ASD has long been documented in the literature. Therefore, the aim of this study was to analyze the alterations of N-acetylaspartate/creatine (NAA/Cr) and choline/Cr (Cho/Cr) ratios in the frontal lobe subcortical white matter (WM) in ASD patients, in order to reveal any alteration of metabolites that might be the expression of specific clinical features of the disorder.


Tutti gli autori

  • DE GIACOMO A.;PESCHECHERA A.;DICUONZO F.;PICARDI F.;MARGARI L.;MARGARI M.;CALDAROLA M.;PALUMBI R.

Titolo volume/Rivista

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Anno di pubblicazione

2018

ISSN

1176-6328

ISBN

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Numero di citazioni Wos

Nessuna citazione

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Numero di citazioni Scopus

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Settori ERC

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Codici ASJC

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