Abstract

Facile, alternative synthetic routes to (RS)-, (R)-, and (S)-3-benzyl-N-(2,6-dimethylphenyl)-1,3-oxazolidine-4-carboxamides (6), a chiral oxazolidine derivative of tocainide, are reported. The synthetic routes described herein also afforded (RS)-, (R)-, and (S)-11, which present the imidazolidin-4-one core and belong to a class of compounds interesting for their biological activities. All the final compounds and intermediates were fully characterized. Enantiomeric excesses of homochiral 6 and 11 were determined by capillary electrophoresis analysis using 2-hydroxypropyl-beta-cyclodextrin or highly sulfated gamma-cyclodextrin as chiral selectors.

Autore Pugliese

• Carocci Alessia , Catalano Alessia , Franchini Carlo , Lentini Giovanni

Tutti gli autori

• CAROCCI A.;CATALANO A.;FRANCHINI C.;LENTINI G.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2011

ISSN

0022-152X

ISBN

Non Disponibile

Numero di citazioni Wos

3

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

2

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile