Exploring the Human Mesenchymal Stem Cell Tubule Communication Network through Electron Microscopy
Abstract
Abstract Cells use several mechanisms to transfer information to other cells. In this study, we describe micro/nanotubular connections and exosome-like tubule fragments in multipotent mesenchymal stem cells (MSCs) from human arteries. Scanning and transmission electron microscopy allowed characterization of sinusoidal microtubular projections (700 nm average size, 200 µm average length, with bulging mitochondria and actin microfilaments); short, uniform, variously shaped nanotubular projections (100 nm, bidirectional communication); and tubule fragments (50 nm). This is the first study demonstrating that MSCs from human arteries constitutively interact through an articulate and dynamic tubule network allowing long-range cell to cell communication.
Anno di pubblicazione
2014
ISSN
0191-3123
ISBN
Non Disponibile
Numero di citazioni Wos
7
Ultimo Aggiornamento Citazioni
Non Disponibile
Numero di citazioni Scopus
8
Ultimo Aggiornamento Citazioni
Non Disponibile
Settori ERC
Non Disponibile
Codici ASJC
Non Disponibile
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