Exploring the Human Mesenchymal Stem Cell Tubule Communication Network through Electron Microscopy

Abstract

Abstract Cells use several mechanisms to transfer information to other cells. In this study, we describe micro/nanotubular connections and exosome-like tubule fragments in multipotent mesenchymal stem cells (MSCs) from human arteries. Scanning and transmission electron microscopy allowed characterization of sinusoidal microtubular projections (700 nm average size, 200 µm average length, with bulging mitochondria and actin microfilaments); short, uniform, variously shaped nanotubular projections (100 nm, bidirectional communication); and tubule fragments (50 nm). This is the first study demonstrating that MSCs from human arteries constitutively interact through an articulate and dynamic tubule network allowing long-range cell to cell communication.


Autore Pugliese

Tutti gli autori

  • RESTA L.

Titolo volume/Rivista

Non Disponibile


Anno di pubblicazione

2014

ISSN

0191-3123

ISBN

Non Disponibile


Numero di citazioni Wos

7

Ultimo Aggiornamento Citazioni

Non Disponibile


Numero di citazioni Scopus

8

Ultimo Aggiornamento Citazioni

Non Disponibile


Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile