Abstract

In this preliminary work the toxic activity of Polycyclic Aromatic Hydrocarbons (PAHs) mix standard solutions was studied using "Caenorhabditis elegans" (C. elegans) as system for biological studies. The nematode cultures were exposed for 3 days to 0.01, 0.1 and 1 ppb (ng/ml) of PAH Mix and even if no morphological alterations were observed on the C. elegans populations, the lethality was about 50% when the PAHs concentrations were equal to 0.1 and 1 ppb. Moreover, the lethality test was performed using an organic extract from a PM10 sample. When the gene expression pattern was analyzed a down regulation of the expression on all the genes considered was observed, indicating that the genotoxic effect was scattered on the entire transcription mechanism. These results indicate that "C. elegans" is an effective model for the study of PAHs toxicity; future studies will be oriented to the toxicity evaluation of extracts from PM2.5 and PM10 samples collected in Apulia cities

Autore Pugliese

• De Gennaro Gianluigi

Tutti gli autori

• DE GIORGI C.;DE GENNARO G.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2010

ISSN

1018-4619

ISBN

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Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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