Abstract

Our group has previously shown that the administration of pasta enriched along with the prebiotic inulin induces a significant reduction in triglyceride and glucose levels with a significant delay in gastric emptying (GE) rates. This protective effect may occur by affecting the release of a number of gut peptides involved in the control of gastrointestinal motility. The aim of the present study was to evaluate the effects of inulin-enriched pasta on the circulating levels of neurotensin (NT), somatostatin (SS), and corticotropin-releasing factor (CRF) in relation to the GE time in young healthy subjects. Methods Twenty healthy young male volunteers completed a randomized double-blind crossover study consisting of a 2-week run-in period and two 5-week study periods (11% inulin-enriched/control pasta), with an 8-week wash-out period in between. Gut peptide concentrations were evaluated by radioimmunoassay. GE time was evaluated by ultrasonography. Results The prebiotic treatment significantly increased the area under the curve (AUC) values of both NT and SS (p\0.05 Dunn’s post-test). With regard to gastric motility, along with a significant delay in both the final time and T1/2 gastric emptying time, a positive correlation was found between T1/2 and SS AUC values (r = 0.57, p = 0.009) in the inulin-enriched pasta group. Conclusion These results support the hypothesis that inulin plays an active role in mechanisms affecting the release of these gut peptides, which may modulate the gastric emptying of digesta.

Autore Pugliese

• Chimienti Guglielmina Alessandra

Tutti gli autori

• CHIMIENTI G.A.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2011

ISSN

1436-6207

ISBN

Non Disponibile

Numero di citazioni Wos

21

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

29

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile