Abstract

MalignantPleuralMesothelioma(MPM)isanaggressiveneoplasm that isveryoftenassociatedwithasbestosexposure.MPMdiagnosisisdifficult, veryoftenrequiringinvasiveapproachessuchasthoracoscopy.Exhaledbreath containshundredsofdifferentvolatileorganiccompounds(VOCs)whichmaybe usedfordiagnosisofvariouspulmonaryandsystemicdisordersincludinglung cancer. Methods: Weenrolled13patientswithanestablisheddiagnosisofMPM,13 healthy controls(HC),and13subjectswithaprofessionalexposuretoasbestos without MPM(EXP).Tedlarbagswereusedtocollecthumanbreath.Samples werecollectedusingasorbent-trapfollowedbythermaldesorptionandanalysis by gaschromatographwithananalyticalmassspectrometer(GC-MS). Results: AnalysisshowedthatthemostabundantVOCs(>15 ng/L)inthein- vestigatedsampleswerecyclopentaneand cyclohexane.Thechemicalprofilewas differentforthesamplesclasses:EXPandMPM,showedalteredlevelsoftoluene, xylene, benzaldehyde,trimethylbenzene, limonene, 2-ethyl-1-hexanol,acetophe- none, cyclopentane.MPMpatientsshowed higherconcentrationofcyclohexane (meanvalue=339.31ng/L)comparedtoEXP(meanvalue=173.06ng/L)and controls(meanvalue=30.68ng/L).ByusingtheTukeyHSDtestitwasfound that cyclohexaneconcentrationforMPMwas significantlydifferentcomparedto HC (p=0.006)whereastheconcentrationforEXPwasnotsignificantlydifferent both comparedtoMPM(p=0.146)andcontrolgroup(p=0.285). Conclusions: BreathAnalysisbyGC-MSmayplayapotentialroleinthenon- invasiveassessmentofMPM.

Autore Pugliese

• Longobardi Francesco , De Gennaro Gianluigi , Resta Onofrio , Dragonieri Silvano

Tutti gli autori

• LONGOBARDI F.;DE GENNARO G.;MUSTI M.;RESTA O.;DRAGONIERI S.

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Anno di pubblicazione

2010

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