cAMP/Ca2+ response-element binding protein CREB plays a central role in the biogenesis of respiratory chain proteins in mammalian cells

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Abstract

In mammalian cells, promotion of mitochondrial biogenesis by various agents involves cAMP and Ca21-mediated signal transduction pathways. Recruitment of these pathways results in phosphorylation by cAMP and Ca21-dependent protein kinases of cAMP/Ca21 response element-binding protein (CREB). Phosphorylation of CREB, bound to transcriptional complexes of target genes, activates a down-stream cascade of transcriptional complexes, which involve in sequence, the nuclear factors TORCs, PGC-1, NRF1 and NRF2, and the mitochondrial factor mitochondrial transcriptional factor A. CREB also binds directly to the D-loop of mitochondrial DNA and activates its expression. Activation of this network of transcriptional complexes results in concerted promotion of the expression of nuclear and mitochondrial genes encoding subunits of oxidative phosphorylation complexes.

Autore Pugliese

Tutti gli autori

  • SIGNORILE A.;PAPA F.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2010

ISSN

1521-6543

ISBN

Non Disponibile

Numero di citazioni Wos

25

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

25

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

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Codici ASJC

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