Bone Involvement in Hodgkin's Lymphoma: Clinical Features and Outcome

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Abstract

Hodgkin's lymphoma (HL) is now a highly curable disease, with an improving 5-year survival rate that has now reached 86%. At the time of presentation, HL is usually almost entirely confined to the lymph nodes. We performed a retrospective single-institution study of 384 cases with a median follow-up of 44 months, with the aim of identifying clinical and radiological characteristics and outcomes of patients with bone HL; 32 patients (8%) had primary bone involvement, always with concurrent nodal disease. These included 22 men (69%) and 10 women (31%) with the median age as 41 years. Advanced stages and nodular sclerosis histology prevailed among the subgroup. Radiographic features of bone HL are not specific but indicate a destructive malignant process with osteosclerosis and/or osteolysis. With current chemotherapeutic regimens, the long-term prognosis of patients with osseous HL appears good. The presence of bone lesions in HL should not be interpreted as implying a worse prognosis than without bone involvement.

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  • STABILE IANORA A.A.;NICCOLI ASABELLA A.;GAUDIO F.;SPECCHIA G.;INGRAVALLO G.;RUBINI G.;SINDACO P.;PEDOTE P.;ALBEROTANZA V.

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Anno di pubblicazione

2018

ISSN

0001-5792

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