Abstract

Migraine is a cyclic disorder, in which functional and morphological brain changes fluctuate over time, culminating periodically in an attack. In the migrainous brain, temporal processing of external stimuli and sequential recruitment of neuronal networks are often dysfunctional. These changes reflect complex CNS dysfunction patterns. Assessment of multimodal evoked potentials and nociceptive reflex responses can reveal altered patterns of the brain's electrophysiological activity, thereby aiding our understanding of the pathophysiology of migraine. In this Review, we summarize the most important findings on temporal processing of evoked and reflex responses in migraine. Considering these data, we propose that thalamocortical dysrhythmia may be responsible for the altered synchronicity in migraine. To test this hypothesis in future research, electrophysiological recordings should be combined with neuroimaging studies so that the temporal patterns of sensory processing in patients with migraine can be correlated with the accompanying anatomical and functional changes.

Autore Pugliese

• De Tommaso Marina , Stramaglia Sebastiano

Tutti gli autori

• DE TOMMASO M.;STRAMAGLIA S.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2014

ISSN

1759-4758

ISBN

Non Disponibile

Numero di citazioni Wos

68

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

71

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile