Aberrant genes promoter methylation in neural crest-derived tumors.

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Abstract

Disturbances in the epigenetic landscape by aberrant methylation of CpG islands can lead to inactivation of cancer-related genes in solid tumors. We analyzed the promoter methylation status of 6 genes previously reported as cancer-specific methylated (MCAM, SSBP2, NISCH, B4GALT1, KIF1A and RASSF1A) in 38 neural crest-derived tumors by quantitative methylation-specific real-time PCR (QMSP). The results demonstrated that the determination of the methylation status of RASSF1A is able to distinguish between normal and tumor samples in cutaneous melanomas, lung carcinoids and small bowel carcinoids. MCAM methylation levels were significantly higher in lung carcinoids tumors (p=0.001), suggesting that this alteration may represent a molecular biomarker in this tumor type.

Autore Pugliese

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  • POETA M.L.;PARRELLA P.;BARBANO R.;FAZIO V.M.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2012

ISSN

0393-6155

ISBN

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Numero di citazioni Wos

Nessuna citazione

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Numero di citazioni Scopus

1

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Settori ERC

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Codici ASJC

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