Abstract

This study evaluates the efficacy and toxicity of dose-dense weekly paclitaxel and carboplatin as neoadjuvant chemotherapy in locally advanced cervical cancer (LACC). We collected 23 cases of LACC treated with weekly paclitaxel and carboplatin for nine cycles: 20 patients had complete or partial response to chemotherapy and were submitted to surgery, 3 with poor response received chemoradiation therapy. Pathologic examination showed complete response in four patients, myometrial invasion <50% in nine and >50% in seven patients, parametrial involvement in two, vaginal metastasis in one and lymphovascular space invasion, with positive margins, in another case. Despite seven patients had radiological evidence of lymph nodes involvement at diagnosis, only one had nodal metastases. Five patients showed grade 3-4 of hematologic toxicity.

Autore Pugliese

• Vimercati Antonella , Cicinelli Ettore , Cormio Gennaro , Resta Leonardo , Bettocchi Stefano , Loizzi Vera

Tutti gli autori

• VIMERCATI A.;CICINELLI E.;CRUPANO F.M.;CORMIO G.;RESTA L.;BETTOCCHI S.;MINICUCCI V.;FUMARULO V.V.;LOIZZI V.;DEL VECCHIO V.

Titolo volume/Rivista

Non Disponibile

Anno di pubblicazione

2018

ISSN

1120-009X

ISBN

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Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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