Toll-like receptor 4-dependent glial cell activation mediates the impairment in memory establishment induced by β-amyloid oligomers in an acute mouse model of Alzheimer's disease

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Abstract

Amyloid-β oligomers (AβO) are species mainly involved in the synaptic and cognitive dysfunction in Alzheimer's disease. Although their action has been described mainly at neuronal level, it is now clear that glial cells govern synaptic activity in their resting state, contributing to new learning and memory establishment. In contrast, when activated, they may lead to synaptic and cognitive dysfunction. Using a reliable acute AβO-mediated mouse model of AD, we explored whether the memory alteration AβOs induce relies on the activation of glial cells, and if Toll-like receptor 4 (TLR4), pivotal in the initiation of an immune response, is involved.

Autore Pugliese

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  • Balducci C. , Frasca A. , Zotti M. , La Vitola P. , Mhillaj E. , Grigoli E. , Iacobellis M. , Grandi F. , Messa M. , Colombo L. , Molteni M. , Trabace L. , Rossetti C. , Salmona M. , Forloni G.

Titolo volume/Rivista

BRAIN BEHAVIOR AND IMMUNITY

Anno di pubblicazione

2016

ISSN

0889-1591

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

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Numero di citazioni Scopus

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Settori ERC

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Codici ASJC

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