Recommendations for the use of hepatitis C virus protease inhibitors for the treatment of chronic hepatitis C in HIV-infected persons. A position paper of the Italian Association for the Study of Infectious and Tropical Disease.

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Abstract

Abstract The efficacy data obtained with boceprevir and telaprevir for persons with hepatitis C virus (HCV) genotype 1 infection raise the question of whether HCV protease inhibitors should be used in human immunodeficiency virus (HIV)/HCV co-infected persons. The Italian Association for the Study of Infectious and Tropical Diseases has made these recommendations to provide the rationale and practical indications for the use of triple anti-HCV therapy in persons living with HIV (PLWHIV). A Writing Committee of experts indicated by the President of the Association and a Consulting Committee con- tributed to the document. The final draft was submitted to the evaluation of external experts and the text modified according to their suggestions and comments. Treatment of HCV co-infection should be considered for all HCV RNA positive PLWHIV. Response-guided therapy with pegylated interferon and ribavirin is the standard treatment of PLWHIV with infection by HCV genotype 2, 3, 4, 5 and 6. Boceprevir and telaprevir should be used to treat HCV genotype 1 infection in HIV/HCV co-infected patients for 48 weeks on an individual basis, with close monitoring of their efficacy and tolerability with concur- rent antiretroviral therapy, taking into account potential drug-drug interactions. The decision to treat a patient or to wait for better treatment options, or to discontinue treatment should be made on an individual basis taking into account pre-treatment variables and the on-treatment HCV RNA kinetics.

Autore Pugliese

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  • Armignacco O , Andreoni M , Sagnelli E , Puoti M , Bruno R , Gaeta GB , Perno CF , Santantonio TA , Bonfanti P , Bonora S , Borderi M , Castagna A , d'Arminio Monforte A , De Luca A , Grossi P , Guaraldi G , Maggiolo F , Mussini C , Sagnelli C , Tavio M , Torti C , Uberti-Foppa C , Andreoni M , Angarano G , Antinori A , Armignacco O , Carosi G , Chirianni A , Di Perri G , Galli M , Lazzarin A , Rizzardini G , Sagnelli E , Taliani G

Titolo volume/Rivista

NEW MICROBIOLOGICA

Anno di pubblicazione

2014

ISSN

1121-7138

ISBN

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