Abstract

The mild cognitive impairment (MCI) is an impairment of cog- nitive abilities that not yet satisfies diagnostic criteria of dementia. Impaired cardiovascular parameters are associated with the risk of cognitive disorders. Low estrogen levels in postmenopause are related to impaired ability of the central nervous system and could explain the high incidence of cognitive disorders in postmenopausal women. The aim of this study was to assess cognitive performances in post- menopausal women affected by MCI and the impact of an HRT combination of low-dose oestradiol plus drospirenone. The evalua- tion of cognitive skills performed with neuropsychological tests showed that women on HRT had higher cognitive performances than controls, in particular they showed higher rates of short and long term memory, attention, verbal fluency and visuospatial perform- ance. These ability are typically involved in the MCI. The beneficial effects of drospirenone on cardiovascular parameters could explain the reduce risk of developing dementia. Introduction Mild cognitive impairment (MCI) identifies a dy- namic transitional state between normal ageing and dementia (1). It is characterized by the impairment of various domains of cognitive performances (memory, attention, language, executive function, visuospatial original article

Autore Pugliese

• Matteo Maria

Tutti gli autori

• De Franciscis P. , Luisi A. , Matteo M. , Basso A. , Cerreto V. , Cicatiello R. , Marcello A. , Colacurci N.

Titolo volume/Rivista

GIORNALE ITALIANO DI OSTETRICIA E GINECOLOGIA

Anno di pubblicazione

2013

ISSN

0391-9013

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

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Numero di citazioni Scopus

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Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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