Atomic force microscopy investigation of morphological changes in living keratinocytes treated with HgCl2 at not cytotoxic doses

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Abstract

Morphological changes of normal human keratinocyte cells have been monitored by means of atomic force microscopy after the exposure at a mercury solution containing HgCl2 at 10−7 M. The measurements have been carried out in contact mode in a thermostated liquid cell, to reproduce a cellular environment similar to the physiologic one. Remarkable alterations of the cellular morphology and volume have been revealed after few minutes from starting the exposure experiment, although the HgCl2 concentration is several orders of magnitudes lower than the cytotoxic value (10−4 M). The atomic force microscopy technique results to be a powerful mean to investigate modifications induced in the cell morphology by external chemical agents.

Autore Pugliese

Tutti gli autori

  • M. Lasalvia , G. Perna , E. Mezzenga , E. Migliorini , M. Lazzarino , N. L'Abbate , V. Capozzi

Titolo volume/Rivista

JOURNAL OF MICROSCOPY

Anno di pubblicazione

2011

ISSN

0022-2720

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

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Non Disponibile

Numero di citazioni Scopus

3

Ultimo Aggiornamento Citazioni

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Settori ERC

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Codici ASJC

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