Altered protein expression pattern in skin fibroblasts from parkin-mutant early-onset Parkinson's disease patients

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Abstract

Parkinson's disease (PD) is the most common neurodegenerative movement disorder caused primarily by selective degeneration of the dopaminergic neurons in substantia nigra. In this work the proteomes extracted from primary fibroblasts of two unrelated, hereditary cases of PD patients, with different parkin mutations, were compared with the proteomes extracted from commercial adult normal human dermal fibroblasts (NHDF) and primary fibroblasts from the healthy mother of one of the two patients. The results show that the fibroblasts from the two different cases of parkin-mutant patients display analogous alterations in the expression level of proteins involved in different cellular functions, like cytoskeleton structure-dynamics, calcium homeostasis, oxidative stress response, protein and RNA processing.

Autore Pugliese

Tutti gli autori

  • Lippolis R. , Siciliano R.A. , Pacelli C. , Ferretta A. , Mazzeo M.F. , Scacco S. , Papa F. , Gaballo A. , Dell'Aquila C. , De Mari M. , Papa S. , Cocco T.

Titolo volume/Rivista

BIOCHIMICA ET BIOPHYSICA ACTA

Anno di pubblicazione

2015

ISSN

0006-3002

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

7

Ultimo Aggiornamento Citazioni

Non Disponibile

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile