Abstract

Some quinoline-based compounds bearing a ferrocenyl unit in the 2-position of the heterocyclic system were synthesized from ferrocenyl-o-nitrochalcones through a simple hydrogenation/intramolecular cyclization sequence and fully characterized. The obtained ferrocenyl derivatives were evaluated in vitro as antimalarial agents against chloroquine-susceptible D10 and chloroquine-resistant W2 strains of Plasmodium falciparum and a beneficial effect of the organometallic moiety was evidenced in comparison with the phenyl-substituted analogues. All the ferrocenyl heterocycles inhibited the parasite growth in mM range and the lowest values of IC50 were determined for derivatives containing a dimethylamino group as additional substituent.

Autore Pugliese

• De Donno Maria Antonella , Guido Marcello

Tutti gli autori

• Patti A. , Pedotti S. , Grassi T. , Idolo A. , Guido M. , De Donno A.

Titolo volume/Rivista

JOURNAL OF ORGANOMETALLIC CHEMISTRY

Anno di pubblicazione

2012

ISSN

0022-328X

ISBN

Non Disponibile

Numero di citazioni Wos

14

Ultimo Aggiornamento Citazioni

28/04/2018

Numero di citazioni Scopus

14

Ultimo Aggiornamento Citazioni

28/04/2018

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile