Abstract

New series of pyrido[2,3-d]pyrimidine and 1,8-naphthyridine derivatives were synthesized from 2-amino-6-(phenoxathiin-2-yl)-4-(thiophene-2-yl) nicotinonitrile as starting material, and their structures were characterized on the basis of the spectral data. Most of the synthesized compounds were evaluated for their cytotoxic activity against two cancer cell lines, namely, breast cancer Michigan Cancer Foundation-7 (MCF-7) and prostate cancer human prostatic carcinoma cell line (PC-3) using MTT assay. Some of these compounds showed potent cytotoxic effect concluded from their IC50 values.

Autore Pugliese

• Mele Giuseppe Agostino

Tutti gli autori

• Behalo M. S. , Mele G.

Titolo volume/Rivista

JOURNAL OF HETEROCYCLIC CHEMISTRY

Anno di pubblicazione

2017

ISSN

0022-152X

ISBN

Non Disponibile

Numero di citazioni Wos

4

Ultimo Aggiornamento Citazioni

27/04/2018

Numero di citazioni Scopus

3

Ultimo Aggiornamento Citazioni

28/04/2018

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile