Abstract

SNAREs (N-ethylmaleimide-sensitive factor adaptor protein receptors) are small polypeptides (∼200–400 amino acid) which are characterized by a particular domain, the SNARE motif that can form a coiled-coil structure via hetero-oligomeric interactions. These protein interactions are highly stable leading to the formation of the so-called SNARE complex which allows the membrane fusion. SNAREs also interact with several proteins acting as regulators of SNARE complex formation. By regulating vesicle traffic, SNAREs have a clear influence on several signaling pathways. SNAREs take part to receptors turnover through endocytosis and exocytosis, but they can also directly gate channels and interact with membrane proteins potentially involved in signaling processes. Phosphorylation of SNAREs upon elicitation is known, and hormonal control confirms that SNAREs have a role in signaling processes.

Autore Pugliese

• Di Sansebastiano Gian Pietro

Tutti gli autori

• R. ul Rehman , G.P. Di Sansebastiano

Titolo volume/Rivista

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Anno di pubblicazione

2013

ISSN

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ISBN

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Numero di citazioni Wos

Nessuna citazione

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Numero di citazioni Scopus

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Settori ERC

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Codici ASJC

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