Abstract

The aim of this project was to study the proliferation and differentiation of human Mesenchymal Stem Cells (hMSCs) onto a cellulose-based hydrogel for bone tissue engineering. Methods: Modified-cellulose hydrogel was prepared via double esterification crosslinking using citric acid. The response of hMSCs in terms of cell proliferation and differentiation into osteoblastic phenotype was evaluated by using Alamar blue™ assay and alkaline phosphatase (ALP) activity. Results: The results showed that CMCNa and CMCNa_CA have no negative effect on hMSC, adhesion and proliferation. Moreover, the increase of the ALP expression for CMCNa_CA confirms the ability of the hydrogels to support the osteoblastic differentiation. Conclusions: The cellulose-based hydrogels have a potential application as filler in bone tissue regeneration.

Autore Pugliese

• Sannino Alessandro , Demitri Christian

Tutti gli autori

• M.G. Raucci , M. Antonio Alvarez-Perez , C. Demitri , A. Sannino , L. Ambrosio

Titolo volume/Rivista

JOURNAL OF APPLIED BIOMATERIALS & FUNCTIONAL MATERIALS

Anno di pubblicazione

2012

ISSN

2280-8000

ISBN

Non Disponibile

Numero di citazioni Wos

Nessuna citazione

Ultimo Aggiornamento Citazioni

Non Disponibile

Numero di citazioni Scopus

18

Ultimo Aggiornamento Citazioni

28/04/2018

Settori ERC

Non Disponibile

Codici ASJC

Non Disponibile